Can MPO to MPO Cable Support 100G
Yes. Short answer done.
But if you're still here, there's a lot more going on behind that simple yes.

The 100GBASE-SR4 Thing
So 100G over MPO works through something called 100GBASE-SR4. The SR4 part means Short Reach, 4 lanes. You're running 25Gbps on each lane. Four lanes transmit, four lanes receive. That's 8 fibers total doing the actual work.
Here's where it gets a bit annoying though. Most people grab a 12-fiber MPO cable because that's what's common in the supply chain. You end up with 4 fibers just sitting there doing nothing. Not a huge deal for most setups but it bothers some engineers I know.
24-fiber MPO cables exist too. Overkill for basic 100G but they make sense if you're thinking ahead to 200G or 400G down the road.
Distance Limits
OM3 gets you 70 meters.
OM4 pushes that to 100 meters.
OM5 also hits 100 meters but adds SWDM wavelength support which matters for certain high-density scenarios. Most people just stick with OM4 honestly.
Single-mode is a different animal. PSM4 optics on single-mode MPO can reach 500 meters. Some data center runs need this. Campus backbone connections between buildings. That sort of thing. The cost jumps up considerably though.

Polarity
This section could be its own article. Polarity issues have caused more late-night troubleshooting sessions than anyone wants to admit.
Type-A: key up to key up. Straight through basically. Type-B: key up on one end, key down on the other. This one reverses the fiber positions. Type-C has an internal pair flip happening inside the cable itself.
Get the polarity wrong and the link just won't come up. The optics are fine. The cables test fine on their own. Everything looks good on paper. But the transmit fiber on one end isn't hitting the receive fiber on the other end. Classic mistake. Happens even to experienced techs when they're rushing.
The IEEE and TIA standards have specific guidance on this. TIA-568 Method A, B, and C correspond to these cable types. Mixing methods in the same channel without understanding the flip points creates problems.
Quick Note on Gender
Male MPO connectors have guide pins sticking out. Female ones have the holes. Simple enough.
Trunk cables usually go female-female. Patch cords tend to be male on one end, female on the other. When you mate a male to a female, the pins align the fibers precisely. Two males together won't work. Two females need a male-male adapter or jumper in between.

The Numbers That Actually Matter
Insertion loss needs to stay under 0.35dB per mated pair for 100G links. Some vendors spec tighter at 0.25dB. The IEEE link loss budget assumes certain values and if your connectors exceed those limits, you start eating into your margin.
Return loss minimum is 20dB for multimode applications.
End-face geometry is critical here. The ferrule surface needs specific radius of curvature, fiber protrusion, apex offset values. All of this gets measured during manufacturing. A contaminated connector face throws everything off. One speck of dust can scatter enough light to cause bit errors.
IEC 61300-3-35 covers the inspection criteria. Grade A, B, C, D zones on the fiber core and cladding. Any defect in the core zone is basically a fail condition.
Connector Variants
MPO-12 handles current 100G fine.
MPO-24 is becoming more common with 200G and 400G adoption.
MPO-16 and MPO-32 exist for specific high-density applications. The 32-fiber variant particularly matters for 400G-DR4 and 800G deployments where you need more parallel lanes.

Cable Construction Details
Jacket ratings matter depending on where the cable runs. LSZH for areas requiring low smoke emission. Plenum-rated for air handling spaces in North America. Riser-rated for vertical runs between floors.
Bend radius is typically 10x the cable outer diameter during installation, relaxing to maybe 15x once installed and under no tension. Violate this and you risk macrobend losses. The fiber physically bends too sharply and light escapes the core. Seen it happen in tight cable management situations where someone cinched the velcro straps too aggressively.
Breakout configurations deserve mention too. MPO-to-LC duplex breakouts let you connect 100G switch ports to older 10G or 25G SFP-based equipment. MPO-to-SN and MPO-to-MDC breakouts serve newer very-short-reach applications inside racks.
Real World Consideration
Temperature cycling affects connector performance over time. The materials expand and contract. Repeated mating cycles wear down the ferrule surface. Most manufacturers rate their connectors for 200-500 mating cycles minimum.
For mission-critical links, some operators test every single cable before deployment. Time-domain reflectometer traces, insertion loss at operating wavelengths, visual end-face inspection. Takes longer. Costs more. But catching a marginal connector before it goes live beats troubleshooting a flapping link at 2 AM.
The answer remains yes. MPO to MPO absolutely supports 100G. Getting it to work reliably in production requires attention to the details above.